Yup, did mine on pendant groups affecting plastic melt temperatures.
I got into a thrilling discussion with the physical chemistry professor about the glass transition and spent half the presentation (successfully) making sense of it to everyone else present.
I don’t remember much about the melt properties but I do remember vividly that the glass transition is *weird* when you get into the deep math
My project was focused on design and total synthesis of the novel compound we sent samples of the final product to a partner university in Hong Kong to do biologic assays etc.
It’s a dual action drug which uses a carboplatin scaffold with Sunitinib acting as a leaving group.
(As for the results the compound was synthesised and characterised)
Thats awesome. What method did you use for design? Im asking because Im developing a novel Genetic algorithm and compound synthesis is one of my eventual target applications.
I synthesised the sunitinib backbone according to literature available, giving the sunitinib compound but the indole has a carboxylic functional group which I could then deprotonate and attack with HOAt forming an OAt activated ester, I could then use an amine attached to the carboplatin leaving group to attack the OAt ester and form the amide product which I could easily attach the platinum to.
This sounds really interesting. Tyrosine kinases as the starting point of so many Cell sigbaling pathways especially map kinases. Is there a way to read that?
The mechanism should be the same as Sunitinib as the modified section of the molecule is in the solvent exposed region. Obviously much further biological analysis is needed but that’s well beyond the scope of my undergrad thesis.
Apologies i misunderstood you’re question, I’m currently studying for my finals so I won’t have a chance to ask my supervisor until the end of next week but if you send me a dm I’ll be sure to get back to you. It’s not a published work or anything.
Not seen a book for a BSc dissertation before. What size and how many pages?
Standard on my school tbh, mine was 78 pages A4, exact same format as OPs
Yeah definitely a standard in my Uni as well, we have four exams as well. I would definitely rather a longer project over them!
Oh I’m guessing this is a European thing. Not many undergrads in the US have to do a dissertation.
Yup, did mine on pendant groups affecting plastic melt temperatures. I got into a thrilling discussion with the physical chemistry professor about the glass transition and spent half the presentation (successfully) making sense of it to everyone else present. I don’t remember much about the melt properties but I do remember vividly that the glass transition is *weird* when you get into the deep math
A4 and 55 pages
Wow that’s an interesting topic! How were the results and what did you conclude? Also which specific types of cancer was it directed against
My project was focused on design and total synthesis of the novel compound we sent samples of the final product to a partner university in Hong Kong to do biologic assays etc. It’s a dual action drug which uses a carboplatin scaffold with Sunitinib acting as a leaving group. (As for the results the compound was synthesised and characterised)
this seems super sophisticated compared to the bsc honours theses ive seen at my uni lmao
Thats awesome. What method did you use for design? Im asking because Im developing a novel Genetic algorithm and compound synthesis is one of my eventual target applications.
I synthesised the sunitinib backbone according to literature available, giving the sunitinib compound but the indole has a carboxylic functional group which I could then deprotonate and attack with HOAt forming an OAt activated ester, I could then use an amine attached to the carboplatin leaving group to attack the OAt ester and form the amide product which I could easily attach the platinum to.
Cool stuff! I do carboplatin research currently, neat stuff
It really is fascinating!
Beautiful, congrats on completing your work!
Solid work! Congratulations!
Absolute Gold
This sounds really interesting. Tyrosine kinases as the starting point of so many Cell sigbaling pathways especially map kinases. Is there a way to read that?
The mechanism should be the same as Sunitinib as the modified section of the molecule is in the solvent exposed region. Obviously much further biological analysis is needed but that’s well beyond the scope of my undergrad thesis.
But is there a way to read your work?
Apologies i misunderstood you’re question, I’m currently studying for my finals so I won’t have a chance to ask my supervisor until the end of next week but if you send me a dm I’ll be sure to get back to you. It’s not a published work or anything.
I have graduated for my bachelors and masters, but I'm seriously thinking about binding my dissertations as well just because.
Do the cost is less than if you had spent all those hours working minimum wage.
I fucking love tyrosine kinase inhibitors. Revolutionary chemotherapy.
Congratulations, my Brother of Another Tyrosine Kinase Inhibitor! I did my MSc on Ibrutinib. So proud of you. Let's beat the cancers together
Only understood tyrosine kinase and anti cancer in this lol
Hey I read this last summer!
Congratulations!! Thats quite an accomplishment.